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KMID : 0370219960400050507
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Yakhak Hoeji
1996 Volume.40 No. 5 p.507 ~ p.512
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Synthesis and Biological Evaluation of New Allylamine Antimycotics
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정병호/Chung BH
박은주/문현주/유진철/Park EJ/Moon HJ/Yoo JC
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Abstract
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Some allylamine compounds which are benzothiazole substituants in stead of naphthyl ring in naftifine, antifungal agents, were synthesized as potential antimycotics. The intermediate Schiff bases that were obtained by condensation of 2-aminobenzothiazole and trans-cinnamaldehyde, were reduced to imine compounds to give allylamines (5a-5d) after methylation. These compounds which were tested in vitro against five fungal cell lines containing Trichophyton mentagrophytes, showed no activity in 0.1~100mcg/ml range.
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